Key result
Previous surgery was an independent predictor of surgical site infections, increasing the odds of infection by more than three-fold (AOR 3.22) compared to patients without prior surgery.
Why the study?
What are the patterns of antibiotic use, incidence, and predictors of surgical site infections in a tertiary care teaching hospital in Ethiopia?
Observational (n=131)
No
What are the patterns of antibiotic use, incidence, and predictors of surgical site infections in a tertiary care teaching hospital in Ethiopia?
Odds Ratio: 3.22 (95% CI 1.14–9.13)
Absolute Event Rate: 36.4% vs 15.3%
p-value: p=0.028
In a tertiary hospital in Ethiopia, surgical site infections occurred in 20.6% of patients, with alcohol use and previous surgery identified as independent predictors.
OBJECTIVE: Surgical site infections (SSIs) were the most common healthcare-associated infection mainly in developing countries. Inappropriate use of surgical antibiotic prophylaxis, in terms of antibiotic choice, timing, and duration, can lead to the selection of resistant microorganisms and high costs. The aim of this study was to investigate the pattern of antibiotic use, incidence and predictors of SSIs at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. RESULTS: From 131 patients, 55.7% were male study participants. Ninety (68.7%) patients received preoperative prophylaxis. Ceftriaxone was the most 76 (84.5%) prescribed agent for prophylaxis. Twenty-seven (20.6%) patients developed surgical site infection. Previous surgery AOR = 3.22 (95% CI [1.14-9.13]) and alcohol use AOR = 7.04 (95% CI [2.56-23.12, p = 0.000]) were independent predictors of SSIs in multivariate logistic regression analysis.
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Halawi et al. (2018) conducted an observational in Surgical site infections (n=131). Previous surgery vs. No previous surgery was evaluated on Surgical site infection (SSI) (AOR 3.22, 95% CI 1.14-9.13, p=0.028). Previous surgery was an independent predictor of surgical site infections, increasing the odds of infection by more than three-fold (AOR 3.22) compared to patients without prior surgery.
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