Key result
Opium use in coronary angiography patients was associated with significantly lower SYNTAX scores, SBP, triglycerides, and creatinine, but also reduced LVEF (p < 0.05 to p < 0.01).
Why the study?
Opium has been used traditionally for lowering blood lipids, diabetes, cancer, and postponing cardiac diseases, prompting evaluation of its effects in CAD patients undergoing angiography.
Does opium use affect SYNTAX score and cardiovascular risk factors in angiography patients with coronary artery disease?
Case-Control
Does opium use affect SYNTAX score and cardiovascular risk factors in angiography patients with coronary artery disease?
While opium use in CAD patients is associated with lower SYNTAX scores and triglycerides, it also significantly reduces LVEF, highlighting potential cardiac toxicity.
Opium use should not alter CAD management despite lower SYNTAX scores; hypothesis-generating for net effects on LVEF.
Opium has been used traditionally for lowering blood lipids, diabetes, cancer, and postpone of cardiac diseases. The coronary angiography patients were divided to opium user and control group. SYNTAX score, serum lipid profile, left ventricular ejection fraction (LVEF), systolic and diastolic blood pressure (SBP and DBP) were measured in the case and control groups. The SBP, LVEF, serum levels of triglycerides, creatinine and SYNTAX score in opium user group was significantly lower than non-user group (p < 0.05 to p < 0.01). Although, opium consumption reduced some risk factors, LVEF a key variable for the diagnosis and management of heart failure was also reduced.
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Moezi et al. (2021) conducted a case-control in Coronary artery disease (CAD). Opium use vs. Non-user group (control) was evaluated on SYNTAX score, SBP, LVEF, serum levels of triglycerides, and creatinine (p=p < 0.05 to p < 0.01). Opium use in coronary angiography patients was associated with significantly lower SYNTAX scores, SBP, triglycerides, and creatinine, but also reduced LVEF (p < 0.05 to p < 0.01).
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