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September 11, 2018IJC Heart & VasculatureOpen Access

A study of association between platelet volume indices and ST elevation myocardial infarction

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Key result

Mean platelet volume (8.22 vs 7.74 fL, p=0.005) and platelet distribution width (15.81 vs 15.62 fL, p=0.007) were significantly higher in STEMI patients compared to matched controls.

Why the study?

Are increased platelet volume indices (MPV and PDW) associated with ST elevation myocardial infarction?

Population

104 individuals, comprising 52 STEMI patients before commencing antiplatelet therapy and 52 age and gender…

Comparison

Platelet volume indices vs Age and gender matched controls without history…

Design

Case-control

Authors

BABhawani Yasassri AlvitigalaMAMohammedu Aroos Fathima AzraDKDarshana Kottahachchi

Discussion

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Overview

Elevated MPV and PDW were associated with STEMI; hypothesis-generating for risk markers and requires prospective validation.

Study Design

Type

Case-Control (n=104)

Structured PICO

Are increased platelet volume indices (MPV and PDW) associated with ST elevation myocardial infarction?

P
Population
104 participants comprising 52 STEMI patients before antiplatelet therapy and 52 age- and gender-matched controls without ischemic heart disease.
E
Exposure
Platelet volume indices (mean platelet volume [MPV] and platelet distribution width [PDW])
C
Comparator
Age and gender matched controls without history of ischemic heart disease or antiplatelet therapy
O
Outcome
Association between platelet volume indices (MPV and PDW) and STEMIsurrogate

Main Result

Absolute Event Rate: 8.22% vs 7.74%

p-value: p=0.005

Increased mean platelet volume and platelet distribution width are significantly associated with STEMI and may serve as preliminary markers to identify high-risk patients.

Cite This Study

Alvitigala et al. (2018) conducted a case-control in ST elevation myocardial infarction (n=104). Platelet volume indices (MPV and PDW) vs. Controls without ischemic heart disease was evaluated on Mean platelet volume (MPV) (p=0.005). Mean platelet volume (8.22 vs 7.74 fL, p=0.005) and platelet distribution width (15.81 vs 15.62 fL, p=0.007) were significantly higher in STEMI patients compared to matched controls.

synapsesocial.com/papers/6a80ab1d2ea91e47663d6dabhttps://doi.org/10.1016/j.ijcha.2018.09.001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Platelet Distribution Width Is Associated With ST-Segment Elevation Myocardial Infarction and Thrombolysis Failure2014 · 64 citations
  2. 2Prognostic value of mean platelet volume and platelet distribution width for the outcomes of patients with acute ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention2025 · 2 citations
  3. 3Could Higher Platelet Indices on Admission Predict Re-Infarction & Adverse Outcomes in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention (PPCI)? A Single-Center Experience2024 · 3 citations
  4. 4Association of Mean Platelet volume With Angiographic Thrombus Burden In Patient With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutanous Coronary Intervention2020
  5. 5Increased Mean Platelet Volume (MPV) in Patients with ST Elevation Myocardial Infarction (STEMI) Compared to Non-ST Elevation Myocardial Infarction (NSTEMI) Patients2020 · 1 citations