Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 19, 2007AJP Heart and Circulatory Physiology

Adenovirus-mediated I-Smad7 gene transfer was associated with a significant decrease of collagen synthesis in the presence and absence of TGF-beta(1) compared to LacZ controls.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does adenovirus-mediated I-Smad7 gene transfer reduce collagen production in primary rat cardiac myofibroblasts?

Population

Primary rat cardiac myofibroblasts

Comparison

Adenovirus-mediated I-Smad7 gene transfer vs LacZ controls (Ad-LacZ-infected cells)

Design

Preclinical

Authors

BWBaiqiu WangAOAmer OmarTATatjana Angelovska

Discussion

Loading...

Member takes

Overview

May limit cardiac fibrosis via reduced collagen synthesis in vitro; leaves open in vivo efficacy and clinical translation.

Structured PICO

Does adenovirus-mediated I-Smad7 gene transfer reduce collagen production in primary rat cardiac myofibroblasts?

P
Population
Primary rat cardiac myofibroblasts
I
Intervention
Adenovirus-mediated I-Smad7 gene transfer (at 100 multiplicity of infection)
C
Comparator
LacZ controls (Ad-LacZ-infected cells)
O
Outcome
Net collagen production (measured using hydroxyproline assay)surrogate

Ectopic expression of I-Smad7 reduces collagen synthesis and cell proliferation in cardiac myofibroblasts, highlighting a potential therapeutic strategy for cardiac fibrosis.

Cite This Study

Wang et al. (2007) studied this question.

synapsesocial.com/papers/6a80ab2e2cf87dafd7c8b1e1https://doi.org/10.1152/ajpheart.00910.2006
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fibroblast Smad7 Induction Protects the Remodeling Pressure-Overloaded Heart2024 · 47 citations
  2. 2Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart2002 · 148 citations
  3. 3SMAD7: riding on fibrosis-limiting routes and beyond2025
  4. 4Cardiomyocyte‐Specific Smad7 Protects the Pressure‐Overloaded Heart, Inhibiting the Transforming Growth Factor‐β Receptor 1/Smad2/3 Cascade2026
  5. 5Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling2013 · 70 citations