January 1, 2014Thrombosis and Haemostasis
Activated protein C based therapeutic strategies in chronic diseases
Population
Models of chronic diseases (e.g., diabetic nephropathy, neurodegeneration, wound healing)
Design
Review
Authors
Discussion
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Member takes
Implication
Caution against premature clinical adoption; leaves open tissue-specific APC variant trials in chronic disease.
Structured PICO
P
Population
Models of chronic diseases (e.g., diabetic nephropathy, neurodegeneration, wound healing)
I
Intervention
Activated protein C (aPC) and cytoprotective-selective aPC variants
Activated protein C and its variants show potential for tissue-specific therapeutic approaches in chronic diseases through sustained cytoprotective mechanisms.
Cite This Study
Bock et al. (2014) studied this question.