Why the study?
Does a high-salt diet impair vascular relaxation mechanisms in cerebral arteries in male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats
Comparison
High-salt diet for 3 days or 4 weeks vs Low-salt diet for 3 days or 4 weeks
Design
Preclinical
Follow-up
3 days or 4 weeks
Authors
Loading...
HS diet impairs rat cerebral artery relaxation; hypothesis-generating for salt-sensitive cerebrovascular dysfunction, should not yet change practice.
Does a high-salt diet impair vascular relaxation mechanisms in cerebral arteries in male Sprague-Dawley rats?
A high-salt diet impairs relaxation of cerebral arteries in response to vasodilator stimuli, a defect that can be restored by low-dose angiotensin II infusion.
Lombard et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: