Population
Isolated rat mesenteric resistance arteries
Comparison
Perivascular nerve stimulation and exogenous… vs Baseline or control conditions without specific…
Design
Preclinical
Authors
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May indicate beta-adrenergic KATP-mediated hyperpolarization opposing vasoconstriction in animals; leaves open relevance to human hypertension.
Neurally released catecholamines cause membrane hyperpolarization in arterial muscle cells through the activation of ATP-sensitive K+ channels by beta-adrenoceptors, which may oppose alpha-adrenergic depolarization.
Gotō et al. (2000) studied this question.
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