January 1, 1998AJP Heart and Circulatory Physiology

Characterization and function of Ca2+-activated K+ channels in arteriolar muscle cells

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Population

Hamster cremasteric microcirculation and enzymatically isolated cremasteric arteriolar muscle cells

Comparison

Superfusion with KCa channel antagonists… vs Resting conditions / absence of antagonists

Design

Preclinical

Authors

WJWilliam F. JacksonMichigan State University KBKevin L. BlairWestern Michigan University

Discussion

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Implication

KCa blockade spares resting tone but augments constriction in rodent arterioles; hypothesis-generating for vascular KCa function, no clinical implications yet.

Structured PICO

Population

Hamster cremasteric microcirculation (in vivo) and enzymatically isolated cremasteric arteriolar muscle cells (in vitro)

Intervention

Superfusion with KCa channel antagonists tetraethylammonium (TEA, 1 mM) or iberiotoxin (IBTX, 100 nM)

Comparator

Resting conditions / absence of antagonists

Outcome

Effect on resting arteriolar diameters and single-channel properties (conductance and Ca2+ sensitivity)surrogate

KCa channels are silent in resting cremasteric arterioles due to a high Ca2+ set point but are recruited during vasoconstriction.

Cite This Study

Jackson et al. (1998) studied this question.

synapsesocial.com/papers/6a80b57bcf96de1eb9c89519 https://doi.org/10.1152/ajpheart.1998.274.1.h27

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Implication

KCa blockade spares resting tone but augments constriction in rodent arterioles; hypothesis-generating for vascular KCa function, no clinical implications yet.

Characterization and function of Ca2+-activated K+ channels in arteriolar muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization and function of Ca2+-activated K+ channels in arteriolar muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider