Population
Human arterial smooth muscle and genomic libraries, Xenopus oocytes, and Chinese hamster ovary cells
Comparison
Cloning and expression of hSlo with or without a… vs mSlo channels or hSlo alpha-subunits expressed…
Design
Preclinical
Authors
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Does not support clinical translation; leaves open beta-subunit targeting for human vascular BK channel disorders.
The high calcium sensitivity of vascular smooth muscle BK channels is likely determined by the coexpression of the hSlo alpha-subunit with a specific beta-subunit.
McCobb et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: