Population
Mammalian (human and mouse) brain tissues and BK channels (Slo1)
Comparison
Alternative exon coding for the region from S6… vs Commonly described Slo1 variant
Design
Preclinical
Authors
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Alters BK gating in animal models; leaves open relevance to human neuronal excitability or therapeutic targeting.
The discovery of a mutually exclusive alternative exon in the mammalian Slo1 gene reveals a novel mechanism for fine-tuning neuronal excitability through altered BK channel gating.
Soom et al. (2008) studied this question.
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