July 1, 2002Journal of Biological ChemistryOpen Access

Interacting Effects of N-terminal Variation and Strex Exon Splicing on slo Potassium Channel Regulation by Calcium, Phosphorylation, and Oxidation

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Population

Rat pituitary cell line, GH(4)C(1) expressing native rat Slo (rSlo) potassium channel (BK(Ca); KCNMA1)

Comparison

Inclusion of the strex exon and N-terminal… vs rSlo channels without the strex exon or with…

Design

Preclinical

Authors

CEChristian ErxlebenLoyola University Chicago AEAngela EverhartDuke University CRCharles RomeoNational Institute of Environmental Health Sciences

Discussion

Member takes

Implication

Does not support clinical translation; leaves open physiological roles of strex splicing in cardiovascular oxidative stress.

Structured PICO

Population

Rat pituitary cell line, GH(4)C(1) expressing native rat Slo (rSlo) potassium channel (BK(Ca); KCNMA1)

Intervention

Inclusion of the strex exon and N-terminal variation in rSlo alpha subunits

Comparator

rSlo channels without the strex exon or with different N-terminal variations

Outcome

Channel sensitivity to inhibition by oxidation and stimulation by calciumsurrogate

N-terminal variation and strex exon splicing interact to produce physiologically relevant phenotypes in BK(Ca) channels, affecting their regulation by calcium, phosphorylation, and oxidation.

Cite This Study

Erxleben et al. (2002) studied this question.

synapsesocial.com/papers/6a9239ca8a638c790c5ef746 https://doi.org/10.1074/jbc.m203087200

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Interacting Effects of N-terminal Variation and Strex Exon Splicing on slo Potassium Channel Regulation by Calcium, Phosphorylation, and Oxidation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interacting Effects of N-terminal Variation and Strex Exon Splicing on slo Potassium Channel Regulation by Calcium, Phosphorylation, and Oxidation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider