Why the study?
Does P2Y12 inhibition or deficiency reduce early atherogenesis in ApoE(-/-) mice?
Population
ApoE(-/-) and ApoE(-/-)P2Y12 (-/-) male mice undergoing bone marrow transplantation and fed a western diet
Comparison
Platelet vs. vessel wall P2Y12 deficiency and… vs ApoE(-/-) controls and control mice fed mannitol
Design
Preclinical
Follow-up
4 weeks
Authors
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May not support P2Y12 inhibitors for early atheroma prevention; leaves open vessel wall P2Y12 as a distinct therapeutic target in atherosclerosis models.
Does P2Y12 inhibition or deficiency reduce early atherogenesis in ApoE(-/-) mice?
Vessel wall P2Y12, rather than platelet P2Y12, drives early atherogenesis, suggesting that P2Y12 inhibitors like ticagrelor and clopidogrel may not prevent early atherosclerotic disease.
West et al. (2014) studied this question.
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