The Role of Anti-Glomerular Basement Membrane Antibody in the Pathogenesis of Human Glomerulonephritis
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Discussion
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Implication
Experimental study demonstrates induction of acute glomerulonephritis by anti-GBM antibodies in monkeys, suggesting a direct pathogenic mechanism in human autoimmune nephritis.
Key Points
- Determine whether anti-glomerular basement membrane (anti-GBM) antibodies play a direct pathogenic role in causing human glomerulonephritis.
- Tested serum and kidney eluates from six patients with glomerulonephritis for antibodies that react with glomerular basement membrane antigens in vitro and in vivo.
- Injected purified IgG from serum or kidney eluates of three patients into healthy recipient monkeys to assess passive transfer of renal disease.
- Transfer of anti-GBM IgG from patients induced acute glomerulonephritis in recipient monkeys, with antibodies binding directly at renal injury sites.
- Anti-GBM antibodies were identified in all evaluated cases of Goodpasture's nephritis and in less than half of adult subacute and chronic glomerulonephritis cases.
Cite This Study
Lerner et al. (1967) studied this question.