Catalytic Asymmetric Conjugate Addition on Macrocyclic and Acyclic Enones. Synthesis of R-(-)-Muscone

All articles of this category The asymmetric conjugate addition of diethyl zinc to acyclic enones is described. With 1% Cu(OTf) 2 and 2% of a chiral phosphite ligand, the catalyst allowed ee's up to 92'% to be obtained. The addition of dimethyl zinc to a macrocyclic 15-membered ring enone lead to optically active R -(-)-muscone, in 53% yield and 79% enantiomeric excess. conjugate addition - catalysis - copper - asymmetry - dialkyl zinc - muscone