Introduction: Sepsis is an important cause of neonatal mortality. Developing countries bear a higher burden of neonatal mortality due to neonatal sepsis. Early diagnosis by identifying the clinical signs and symptoms and starting evidence-based empirical antibiotic therapy is key to a better outcome of neonatal sepsis. Thus, identifying the bacteriological profile and their antibiotic sensitivity pattern is important to formulate the antimicrobial policy. Aim: The present study was undertaken to identify the clinic-bacteriological profile of neonatal sepsis cases admitted in the NICU and also to find out the antibiotic sensitivity pattern of isolated organisms. Methods: Two hundred and sixty-two neonates were included in the study who were admitted with possible neonatal sepsis in the NICU in a tertiary care hospital, in West Bengal from January 2023 to January 2025. Neonatal sepsis was confirmed by blood culture and an antibiogram was performed to get the antibiotic sensitivity pattern as per CLSI guidelines. Data were analysed using Microsoft Excel version 2019 and SPSS 25. Result: The prevalence of culture-positive sepsis was 20.73%. Gram-negative organisms have been isolated in 45.3% of cases and the remaining 54.7% were gram-positive sepsis. Staphylococcus aureus was the predominant organism. Burkholderia cepacia, CONS, and Klebsiella spp. are other important causative organisms. A higher prevalence of antibiotic resistance has been observed in the present study. Conclusion: Regular follow-up on bacteriological profiles and antibiotic sensitivity tests are important to identify the predominant local bacteriological trends and this can help in formulating the antibiotic policy.
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A 2025 study studied this question.
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