Case report demonstrates regression of basal ganglial signal hyperintensity in a total parenteral nutrition patient, indicating manganese-induced brain alterations are reversible.
The authors describe magnetic resonance (MR) imaging findings in a patient receiving long-term total parenteral nutrition (TPN) therapy in whom parenteral manganese administration was experimentally discontinued. MR imaging performed while the patient was receiving standard TPN solution demonstrated marked hyperintensity of the globi pallidi on T1-weighted images. Following cessation of parenteral manganese administration for 1 year, repeat MR imaging demonstrated regression of the abnormal signal intensity.
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Mirowitz et al. (1992) studied this question.
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