Why the study?
Excess and early cardiovascular disease occurs in patients with unipolar depression and bipolar disorder-depressive episode, motivating evaluation of atherogenic indices and HDL-related ratios in these populations.
Do patients with unipolar depression and bipolar disorder-depressive episode have worse cardiovascular risk parameters compared to healthy controls?
Do patients with unipolar depression and bipolar disorder-depressive episode have worse cardiovascular risk parameters compared to healthy controls?
Patients with unipolar and bipolar depression exhibit significantly higher atherogenic and inflammatory lipid ratios compared to healthy controls, suggesting an increased cardiovascular risk that correlates with disease duration.
Elevated atherogenic indices may signal higher CV risk in depression; leaves open causality and need for prospective outcome trials.
Objective: There is strong evidence that excess and early cardiovascular disease (CVD) occurs in patients with unipolar depression (UD) and bipolar disorder -depressive episode (BD-d).The aim of this study is to evaluate plasma atherogenic index (AIP), atherogenic coefficient (AC), Castelli risk index I-II (CRI-I and II) and high-density lipoprotein (HDL) related ratios in UD, BD-d and HC. Methods:The present study was designed as a retrospective and observational study.This study included 128 patients with UD, 184 individuals as a healthy control group and 34 patients with BD-d.AIP [log (TG/HDL)], AC [(TC-HDL)/HDL], CRI-I (TC/HDL) and II (LDL/ HDL), MHR (monocyte/HDL), NHR (neutrophil/HDL), PHR (platelet/HDL) and LHR (lymphocyte/HDL) were calculated in these three groups.ANCOVA was used for age-and sexadjusted means.Results: There were significant differences in fasting glucose (FG) (p=0.016),LDL (p=0.004),HDL (p<0.001),TG (p<0.001),TC (p=0.01),AIP (p<0.001),NHR (p<0.001),MHR (p=0.007),LHR (p<0.001),PHR (p<0.001) between three groups.All these metabolic parameters were correlated with duration of disorder. Conclusion:Along with the care of a depressive episode, the management of abnormal metabolic parameters should be planned during diagnosis, follow-up, and treatment.Assessment of AIP and NHR, especially in chronic and unresponsive processes, may be useful in both disorders.In future studies, it is recommended to conduct large-scale studies that are prospectively designed, that monitor the severity of the disease, and that evaluate the CVD risk parameters and treatment of the participants.
No takes yet. Share an insight, caveat, or question.
Burcu Kök Kendirlioğlu (2023) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: