Why the study?
Does instantaneous wave-free ratio (iFR) accurately assess the functional severity of moderate coronary artery stenoses compared to fractional flow reserve (FFR) in an all-comer patient population?
Population
356 consecutive all-comer patients with 515 intermediate coronary stenoses at a single center in The…
Comparison
Instantaneous wave-free ratio measurement using… vs Fractional flow reserve measurement during…
Design
Cohort
Authors
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High NPV supports deferring revascularization without adenosine in moderate stenoses; leaves open whether iFR can replace FFR.
Does instantaneous wave-free ratio (iFR) accurately assess the functional severity of moderate coronary artery stenoses compared to fractional flow reserve (FFR) in an all-comer patient population?
Real-time iFR measurements have a high negative predictive value compared to FFR for assessing moderate coronary stenoses, allowing for reduced adenosine exposure, procedure time, and costs, though diagnostic accuracy is moderate (82%).
Pisters et al. (2018) studied this question.
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