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Clinical evaluation demonstrates benefits of peppermint oil on lipid metabolism in patients with irritable bowel and metabolic syndrome, suggesting potential as combined pathogenetic therapy.
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, affecting almost 20% of the population, causing significant functional and socioeconomic burden. An existing association between functional bowel disorders, metabolic syndrome (MS) and its components has been proven: patients with IBS have an increased risk of developing MS, including higher BMI, dyslipidemia, hyperglycemia, insulin resistance, and cardiovascular disorders. The authors studied the therapeutic effectiveness of peppermint oil (the drug Kapsumen) on lipid metabolism in 40 patients with IBS and metabolic syndrome. The obtained data allow the use of pleiotrope effect of peppermint oil (Kapsumen drug) as a means of pathogenetic therapy in combination of IBS with manifestations of MS.
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Sergienko et al. (2025) studied this question.
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