Key result
Exercise and respiratory training improves 6MWD by ~111 m vs control in severe pulmonary hypertension.
Why the study?
Pulmonary hypertension is associated with restricted physical capacity, limited quality of life, and poor prognosis, but the effects of exercise and respiratory training in severe symptomatic PH were not previously evaluated in a prospective randomized study.
Does exercise and respiratory training improve exercise capacity and quality of life in patients with severe symptomatic pulmonary hypertension?
Comparison
Exercise and respiratory training plus stable disease-targeted medication vs stable disease-targeted medication alone
Design
Prospective randomized controlled trial
Follow-up
15 weeks
Authors
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May support supervised training in severe PH; leaves open confirmation of safety and efficacy in larger trials.
RCT (n=30)
randomly assigned
Does exercise and respiratory training improve exercise capacity and quality of life in patients with severe symptomatic pulmonary hypertension?
Mean Difference: 111 (95% CI 65–139)
p-value: p=<0.001
Exercise and respiratory training as an adjunct to medical therapy significantly improves 6-minute walking distance and quality of life in patients with severe pulmonary hypertension.
Mereles et al. (2006) conducted an RCT in Severe symptomatic pulmonary hypertension (n=30). Exercise and respiratory training vs. Control was evaluated on Changes from baseline to week 15 in the distance walked in 6 minutes and in scores of the Short Form Health Survey quality-of-life questionnaire (MD 111 m, 95% CI 65 to 139, p=<0.001). Exercise and respiratory training significantly improved the 6-minute walking distance compared to control in patients with severe pulmonary hypertension (mean difference 111 m; 95% CI 65-139; P<0.001).
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