June 9, 2021Frontiers in Cardiovascular MedicineOpen Access

Sex-Specific Clinical Characteristics and Long-Term Outcomes in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries

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Why the study?

Sex-based disparities among patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) remain largely unreported.

Does female sex affect the risk of major adverse cardiovascular events in patients with MINOCA compared to male sex?

Structured PICO

Does female sex affect the risk of major adverse cardiovascular events in patients with MINOCA compared to male sex?

Population

1,179 patients with myocardial infarction with non-obstructive coronary arteries (MINOCA), mean age 55.7 years, 26.5% female (867 men, 312 women), single-center in China. Excluded patients with obstructive CAD, prior revascularization, thrombolytic therapy for STEMI, alternate reasons for elevated troponin, lack of baseline data, or lost to follow-up.

Intervention

Female sex (observational exposure)

Comparator

Male sex

Outcome

Composite of major adverse cardiovascular events (MACE), including all-cause death, non-fatal reinfarction, revascularization, non-fatal stroke, and hospitalization for unstable angina or heart failure, evaluated as time to first event over a mean follow-up of 41.7 months.composite

In patients with MINOCA, long-term cardiovascular outcomes are similar between men and women, despite women presenting at an older age and with more comorbidities.

Limitations

Single-center study
Observational design cannot prove causation
Possible unmeasured confounding variables
Exact mechanism for every MINOCA patient not captured
Percentage of menopausal women not recorded

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Women's higher-risk profiles need not prompt more aggressive MINOCA care; leaves open validation beyond this observational Chinese series.

Cite This Study

Gao et al. (2021) studied this question.

synapsesocial.com/papers/6a80f81cada1eccddc3380fd https://doi.org/10.3389/fcvm.2021.670401

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Implication

Women's higher-risk profiles need not prompt more aggressive MINOCA care; leaves open validation beyond this observational Chinese series.

Sex-Specific Clinical Characteristics and Long-Term Outcomes in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Sex-Specific Clinical Characteristics and Long-Term Outcomes in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider