Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current.
Population
Isolated canine ventricular epicardial and endocardial tissues and myocytes
Comparison
Simulated ischemia with or without… vs Baseline conditions and comparison between…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Ito inhibition may attenuate epicardial ischemia sensitivity in models; leaves open translation to human arrhythmia prevention.
Structured PICO
P
Population
Isolated canine ventricular epicardial and endocardial tissues and myocytes
I
Intervention
Simulated ischemia (hyperkalemia, hypoxia, and acidosis) with or without 4-Aminopyridine (Ito inhibitor) or altered stimulation protocols
C
Comparator
Baseline conditions and comparison between epicardium and endocardium
O
Outcome
Action potential duration and plateau characteristicssurrogate
The presence of a prominent transient outward current (Ito) in canine ventricular epicardium contributes to its selective electrical depression during ischemia, providing an electrophysiological substrate for reentrant arrhythmias.
Cite This Study
Charles Antzelevitch (1993) studied this question.