Why the study?
To review the roles of VLDL receptors in lipoprotein metabolism under physiological conditions and in atherogenesis under nonphysiological conditions.
Key points are not available for this paper at this time.
Design
Review
No practice change for remnant or Lp(a) management; leaves open VLDL receptor targeting in atherogenesis.
PURPOSE OF REVIEW: My group previously discovered and characterized the rabbit and human VLDL receptors. For more than 30 years, I have focused on research regarding the functions of VLDL receptors in the fields of lipoprotein metabolism and atherogenesis. In this review, I introduce the roles of VLDL receptors in lipoprotein metabolism under physiological conditions and in atherogenesis under nonphysiological conditions. RECENT FINDINGS: I propose that the VLDL receptor plays key roles in the metabolism of postprandial remnant lipoproteins in concert with lipoprotein lipase (LPL). Furthermore, I propound a new mechanism for macrophage foam cell formation via VLDL receptors by remnant lipoproteins and lipoprotein(a) [Lp(a)] in addition to scavenger receptor pathways. SUMMARY: The VLDL receptor is a so-called macrophage β-VLDL receptor, which is involved in macrophage foam cell formation by remnant lipoproteins. Furthermore, Lp(a) is a VLDL receptor ligand and is directly taken up through macrophage VLDL receptors for macrophage foam cell formation. Additionally, the roles of VLDL receptors in atherogenesis are canvassed. SUPPLEMENTARY VIDEO ABSTRACT: http://links.lww.com/COL/A21.
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A 2021 study studied this question.
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