June 1, 1995Journal of Biological ChemistryOpen Access

Enhancement of the Binding of Triglyceride-rich Lipoproteins to the Very Low Density Lipoprotein Receptor by Apolipoprotein E and Lipoprotein Lipase

View Full Paper

Ask AI

Bookmark

Population

Chinese hamster ovary (CHO) cells transfected with rabbit or human VLDL receptor cDNA

Comparison

Preincubation of human VLDL with recombinant… vs Human VLDL without pretreatment or cells without…

Design

Preclinical

Authors

STSadao TakahashiKagawa Nutrition University JSJinya SuzukiUniversity of Fukui MKMitsuyuki KohnoUniversity of Fukui

Discussion

Member takes

Implication

Supports VLDL receptor role in remnant uptake in vitro; leaves open its physiologic or therapeutic relevance in humans.

Structured PICO

Population

Chinese hamster ovary (CHO) cells transfected with rabbit or human VLDL receptor cDNA

Intervention

Preincubation of human VLDL with recombinant human apolipoprotein E (apoE) or lipoprotein lipase (LPL), or co-transfection with human LPL cDNA

Comparator

Human VLDL without pretreatment or cells without LPL co-transfection

Outcome

Binding, internalization, and degradation of VLDLsurrogate

Lipoprotein lipase and apolipoprotein E enhance the binding of triglyceride-rich lipoproteins to the VLDL receptor, suggesting its role as a receptor for remnant lipoproteins in extrahepatic tissues.

Cite This Study

Takahashi et al. (1995) studied this question.

synapsesocial.com/papers/6a70309184cc45bb7bdfb7b8 https://doi.org/10.1074/jbc.270.26.15747

View Full Paper

Ask AI

Bookmark

Enhancement of the Binding of Triglyceride-rich Lipoproteins to the Very Low Density Lipoprotein Receptor by Apolipoprotein E and Lipoprotein Lipase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Enhancement of the Binding of Triglyceride-rich Lipoproteins to the Very Low Density Lipoprotein Receptor by Apolipoprotein E and Lipoprotein Lipase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider