July 1, 1996Journal of Biological ChemistryOpen Access

Lipoprotein Lipase Binds to Low Density Lipoprotein Receptors and Induces Receptor-mediated Catabolism of Very Low Density Lipoproteins

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Structured PICO

Population

Normal human foreskin fibroblasts (FSF cells), LDL receptor-negative fibroblasts, normal murine embryonic fibroblasts, and LRP-deficient murine embryonic fibroblasts

Intervention

Lipoprotein lipase (LPL) and lovastatin treatment

Comparator

LDL receptor-negative fibroblasts, LRP-deficient murine embryonic fibroblasts, or untreated cells

Outcome

VLDL binding and catabolismsurrogate

Lipoprotein lipase binds to LDL receptors and mediates LPL-dependent catabolism of large VLDL, with the carboxyl-terminal domain of LPL contributing to this interaction.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May link statins to enhanced VLDL clearance via LPL; hypothesis-generating and should not yet change practice.

Cite This Study

Medh et al. (1996) studied this question.

synapsesocial.com/papers/6a702f1a26770c2b8de06016 https://doi.org/10.1074/jbc.271.29.17073

View Full Paper

Ask AI

Bookmark

Lipoprotein Lipase Binds to Low Density Lipoprotein Receptors and Induces Receptor-mediated Catabolism of Very Low Density Lipoproteins

Structured PICO

Discussion

Implication

Cite This Study

Lipoprotein Lipase Binds to Low Density Lipoprotein Receptors and Induces Receptor-mediated Catabolism of Very Low Density Lipoproteins

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider