Water‐Soluble, Donor–Acceptor Biphenyl Derivatives in the 2‐(o‐Nitrophenyl)propyl Series: Highly Efficient Two‐Photon Uncaging of the Neurotransmitter γ‐Aminobutyric Acid at λ=800 nm

Rattling the cage: The two γ-aminobutyric acid (GABA) derivatives 1 and 2 exhibit efficient and rapid (<5×10−6 s) GABA photorelease upon one-photon excitation combined with two-photon uncaging cross-section at λ=800 nm. Compounds 1 and 2 were successfully used for two-photon GABA release in intact brain tissue, thus offering attractive perspectives in chemical neurosciences.