What question did this study set out to answer?

To evaluate the clinical efficacy and safety of hydroxychloroquine treatment in patients diagnosed with COVID-19.

March 30, 2020Open Access

Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial

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Authors

ZCZhaowei ChenShanghai Medical College of Fudan University JHJijia HuFoundation for Innovative New Diagnostics ZZZongwei ZhangHarbin Institute of Technology

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Implication

Randomized trial demonstrates faster recovery and improved pneumonia resolution with hydroxychloroquine in patients with COVID-19, suggesting potential therapeutic benefit.

Key Points

To evaluate the clinical efficacy and safety of hydroxychloroquine treatment in patients diagnosed with COVID-19.
Parallel-group randomized clinical trial (ChiCTR2000029559) conducted at Renmin Hospital of Wuhan University from February 4 to February 28, 2020.
Enrolled 62 COVID-19 patients randomized equally to standard care alone (n=31) or standard care plus 5 days of hydroxychloroquine at 400 mg/day (n=31).
Evaluated time to clinical recovery (body temperature and cough remission), clinical characteristics, and chest radiological absorption at baseline and after 5 days.
Time to clinical recovery was significantly shortened in the hydroxychloroquine group, driven by faster body temperature normalization and cough remission.
Radiological pneumonia improvement occurred in 80.6% (25 of 31) of patients receiving hydroxychloroquine compared with 54.8% (17 of 31) in the control group.
Progression to severe illness occurred in 4 patients (all in the control group), while mild adverse reactions occurred in 2 patients receiving hydroxychloroquine.

Cite This Study

Chen et al. (2020) studied this question.

synapsesocial.com/papers/6a811ebefd865eccc665f416 https://doi.org/10.1101/2020.03.22.20040758

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Implication

Randomized trial demonstrates faster recovery and improved pneumonia resolution with hydroxychloroquine in patients with COVID-19, suggesting potential therapeutic benefit.

Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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