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May 7, 2014PLoS ONEOpen Access

Prefrontal Response and Frontostriatal Functional Connectivity to Monetary Reward in Abstinent Alcohol-Dependent Young Adults

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Population

48 young adults, mean age 27.2, matched for age, sex, race, and smoking habits.

Comparison

fMRI during a block-design monetary reward task vs Psychiatrically healthy adults matched for age…

Design

Case-control

Authors

EFErika E. ForbesEREric E. RodriguezSMSamuel C. Musselman

Discussion

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Overview

Altered frontostriatal reward responses may underlie addiction vulnerability; leaves open whether these markers predict outcomes or guide interventions.

Structured PICO

P
Population
48 young adults (24 with DSM-IV alcohol dependence and 2-week monitored abstinence, 24 psychiatrically healthy controls), mean age 27.2, matched for age, sex, race, and smoking habits.
I
Intervention
fMRI during a block-design monetary reward task (card-guessing game)
C
Comparator
Psychiatrically healthy adults matched for age, sex, race, and smoking habits
O
Outcome
Neural response and functional connectivity (specifically frontostriatal connectivity) during monetary rewardsurrogate

Alcohol dependence in young adults is associated with blunted prefrontal cortical response to non-drug rewards and disrupted frontostriatal connectivity, suggesting weak regulation of ventral striatal response.

Cite This Study

Forbes et al. (2014) studied this question.

synapsesocial.com/papers/6a812a7317c102c6716485cbhttps://doi.org/10.1371/journal.pone.0094640
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