Why the study?
Does 17beta-estradiol administration improve cardiovascular and hepatocellular functions in male rats following trauma-hemorrhage?
Population
Adult male Sprague-Dawley rats undergoing trauma-hemorrhage
Comparison
17beta-estradiol injected subcutaneously 15… vs Equal volume of vehicle injected subcutaneously
Design
Preclinical
Follow-up
24 hours
Authors
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Should not alter trauma resuscitation; leaves open estrogen's role in human hemorrhagic shock pending trials.
Does 17beta-estradiol administration improve cardiovascular and hepatocellular functions in male rats following trauma-hemorrhage?
Estrogen administration appears to restore cardiovascular and hepatocellular functions after trauma-hemorrhage in male rats.
Mizushima et al. (2000) studied this question.
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