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The incidence of cytomegalic inclusion disease (CMID) has shown a significant increase in recent years in children receiving intensive chemotherapy for acute leukemia¹,²and in patients receiving immunosuppressive drugs following renal transplantation.³,⁴The clinical course of CMID in two children with acute leukemia who died with extensive interstitial pneumonitis due to cytomegalovirus (CMV) infection has been described.²The simultaneous use of several antineoplastic agents apparently suppresses immunologic responses to a clinically significant degree. Antiviral effects of floxuridine (2′-deoxy-5-fluorouridine or FUDR) have been demonstrated conclusively. In infected tissue cultures, floxuridine prevents the formation of infectious CMV particles and of intranuclear inclusions; these effects may be prevented by simultaneous treatment of the infected culture with thymidine.⁵In the previously reported case of a child with CMID complicating acute leukemia, floxuridine therapy produced transient improvement.² The purpose of this paper is to evaluate further the effects of floxuridine
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Ayten Cangır (1967) studied this question.
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