Evidence is presented which indicates that intravenous infusion of 2 g/kg of ethanol produced depression of both serotonin and norepinephrine levels in the brain stem of rabbit. The parallel depletion of both neurohormones persisted long after ethanol had disappeared, an effect which is reminiscent of the action of reserpine. Chronic administration of alcohol for 7 days produced 50% decrease in both serotonin and norepinephrine levels in rabbit brain stem.
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Gursey et al. (1960) studied this question.