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April 9, 2025Open Access

MASLD independently predicted a 63% higher cardiovascular mortality risk (adjusted HR=1.63, 95% CI 1.05-2.52, p=0.03).

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Why the study?

To investigate the epidemiological burden of MASLD across CKM stages, evaluate its association with cardiovascular mortality, and explore the mediating role of insulin resistance.

Does the presence of MASLD increase cardiovascular mortality in adults with Cardiovascular-Kidney-Metabolic syndrome stages 1-4?

Population

9,093 adults with CKM stages 1–4 from NHANES (2009–2018)

Comparison

MASLD (usFLI ≥ 30) vs non-MASLD across CKM stages

Design

Retrospective cohort study using NHANES survey data

Authors

ZLZhuoxing LiChengdu Medical CollegeQYQianyu YangNational Institute for Radiological ProtectionMXMao XiaoSinopec (China)

Discussion

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Member takes

Overview

Supports MASLD assessment in CKM syndrome risk stratification; leaves open causality and intervention effects.

Structured PICO

Does the presence of MASLD increase cardiovascular mortality in adults with Cardiovascular-Kidney-Metabolic syndrome stages 1-4?

P
Population
9,093 adults with Cardiovascular-Kidney-Metabolic syndrome (CKM) stages 1-4 from the NHANES database (2009-2018), mean age 49.89 years, 49.47% male, U.S.-based.
I
Intervention
Presence of metabolic dysfunction-associated steatotic liver disease (MASLD), defined by ultrasound-based Fatty Liver Index (usFLI) ≥ 30
C
Comparator
Absence of MASLD (usFLI < 30)
O
Outcome
Cardiovascular mortalityhard clinical

In patients with Cardiovascular-Kidney-Metabolic syndrome, MASLD is associated with a stage-dependent increase in prevalence and a 63% higher risk of cardiovascular mortality, with insulin resistance mediating a significant portion of this risk.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6a813a2ada9cafc35e339563https://doi.org/10.1101/2025.04.07.25325431
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association2023 · 1,330 citations
  2. 2Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls2009 · 7,417 citations
  3. 3Hepatic steatosis, metabolic dysfunction and risk of mortality: findings from a multinational prospective cohort study2024 · 33 citations
  4. 4Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease2010 · 1,928 citations
  5. 5Insulin resistance: Review of the underlying molecular mechanisms2018 · 964 citations