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Mitochondrial research may guide cardiomyopathy therapies; leaves open targeted interventions pending prospective validation.
The diagnosis of cardiomyopathy is mainly based on clinical and morphological criteria. While metabolic, viral, chemical, genetic, and immunological factors are often proposed as causes of cardiomyopathy, little is known about the role of the respiratory chain and other biochemical mitochondrial defects in this group of diseases. Research on the biochemistry and molecular biology of cardiomyopathies offers an opportunity for a better understanding of the pathogenesis and for finding specific therapy.
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Marı́n-Garcı́a et al. (1994) studied this question.
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