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March 30, 2012PLoS ONE61 citationsOpen Access

High Viral Load of Human Bocavirus Correlates with Duration of Wheezing in Children with Severe Lower Respiratory Tract Infection

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Why the study?

Does high HBoV viral load correlate with longer duration of wheezing and hospitalization in children with severe LRTI?

Population

186 hospitalized children with severe lower respiratory tract infection (LRTI) who underwent bronchoscopy

Comparison

High viral load of Human bocavirus vs Low viral load of HBoV (<10^4 copies/mL)

Design

Cohort

Authors

YDYu DengXGXiao-yang GuXZXiaodong Zhao

Discussion

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Overview

High HBoV load associated with prolonged wheezing/hospitalization in pediatric LRTI; leaves open whether viral quantification informs prognosis or management.

Structured PICO

Does high HBoV viral load correlate with longer duration of wheezing and hospitalization in children with severe LRTI?

P
Population
186 hospitalized children with severe lower respiratory tract infection (LRTI) who underwent bronchoscopy
I
Intervention
High viral load of Human bocavirus (HBoV) (>10^4 copies/mL)
C
Comparator
Low viral load of HBoV (<10^4 copies/mL)
O
Outcome
Duration of wheezing and hospitalization

High HBoV viral load is associated with more severe lower respiratory tract symptoms, including longer duration of wheezing and hospitalization in children with severe LRTI.

Cite This Study

Deng et al. (2012) studied this question.

synapsesocial.com/papers/6a81420d407ce5842fa8cd43https://doi.org/10.1371/journal.pone.0034353
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