Why the study?
Does aspirin and dipyridamole reduce intimal hyperplasia in experimental vein grafts and injured vessels in rhesus monkeys?
Population
12 rhesus monkeys undergoing bilateral vein bypass grafts in the iliac arteries, with adventitial stripping…
Comparison
Aspirin and dipyridamole vs Placebo
Design
Preclinical
Follow-up
16 weeks
Authors
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Hypothesis-generating in primate grafts; human trials needed before changing antiplatelet strategies in bypass surgery.
Does aspirin and dipyridamole reduce intimal hyperplasia in experimental vein grafts and injured vessels in rhesus monkeys?
Aspirin and dipyridamole significantly decrease intimal hyperplasia in experimental vein grafts and balloon-injured vessels in a primate model.
McCann et al. (1980) studied this question.
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