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April 22, 2004Angewandte Chemie

Nickel‐Catalyzed Cross‐Coupling of Aryl Grignard Reagents with Aromatic Alkyl Ethers: An Efficient Synthesis of Unsymmetrical Biaryls

John W. Dankwardt

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Abstract

Nachschub für die Biaryl-Synthese: Aromatische Ether reagieren in einer Ni-katalysierten Kreuzkupplung mit Aryl-Grignard-Reagentien in ausgezeichneten Ausbeuten zu unsymmetrischen Biarylen (siehe Schema). Die Wahl des Nickel-Katalysators und des Lösungsmittels ist für hohe Umsätze entscheidend.

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John W. Dankwardt (2004) studied this question.

synapsesocial.com/papers/6a8150fd1325e503433c8b1e https://doi.org/10.1002/ange.200453765

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