What question did this study set out to answer?

To elucidate the molecular mechanism by which CLOCK and CYCLE initiate circadian clock function in canonical and ectopic Drosophila tissues.

September 25, 2017Proceedings of the National Academy of SciencesOpen Access

CLOCK stabilizes CYCLE to initiate clock function in Drosophila

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Authors

TLTianxin LiuUniversity of Jinan GMGuruswamy MaheshCenter for Cancer Research WYWangjie YuKunming University of Science and Technology

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Implication

Laboratory study demonstrates that CLOCK stabilizes CYCLE to initiate circadian rhythms in Drosophila, suggesting minimal requirements for generating ectopic cellular clocks.

Key Points

To elucidate the molecular mechanism by which CLOCK and CYCLE initiate circadian clock function in canonical and ectopic Drosophila tissues.
Analyzed CLOCK and CYCLE protein stability and interactions in Drosophila brain neurons and peripheral tissues.
Assessed the genetic components, including cryptochrome, required to induce ectopic circadian transcriptional feedback loops in naive cells.
CLOCK prevents rapid degradation of CYCLE by stabilizing it within both native circadian neurons and ectopic cell types.
Ectopic clock initiation requires the combined expression of Clock, cycle, and cryptochrome to establish autonomous molecular rhythms.

Cite This Study

Liu et al. (2017) studied this question.

synapsesocial.com/papers/6a815329080e7f4ac74d682d https://doi.org/10.1073/pnas.1707143114

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Implication

Laboratory study demonstrates that CLOCK stabilizes CYCLE to initiate circadian rhythms in Drosophila, suggesting minimal requirements for generating ectopic cellular clocks.

CLOCK stabilizes CYCLE to initiate clock function in Drosophila

Discussion

Member takes

Implication

Key Points

Cite This Study

CLOCK stabilizes CYCLE to initiate clock function in Drosophila

Discussion

Member takes

Implication

Key Points

Cite This Study

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