What question did this study set out to answer?

To determine whether amyloid beta plaques and soluble oligomers trigger neuronal mitochondrial oxidative stress in the living brain and whether mitochondria-targeted therapies can mitigate this toxicity.

June 15, 2022Open Access

Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease

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To determine whether amyloid beta plaques and soluble oligomers trigger neuronal mitochondrial oxidative stress in the living brain and whether mitochondria-targeted therapies can mitigate this toxicity.
Expressed a genetically encoded fluorescent ratiometric reporter of mitochondrial oxidative stress in Alzheimer's disease mouse models.
Performed intravital multiphoton microscopy to track neuronal mitochondrial redox state relative to amyloid beta plaques and applied soluble oligomers.
Evaluated neuroprotective interventions by pharmacologically blocking mitochondrial calcium influx and administering the mitochondria-targeted antioxidant SS31.
Direct in vivo imaging demonstrated marked increases in neuronal mitochondrial oxidative stress associated with both amyloid beta plaque deposition and topical application of soluble oligomers.
Mitochondrial oxidative stress in neurons was successfully suppressed by blocking calcium influx into mitochondria.
Treatment with the mitochondria-targeted antioxidant SS31 eliminated amyloid-beta-induced mitochondrial oxidative stress.

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Implication

In vivo imaging study reveals amyloid beta aggregates drive neuronal mitochondrial oxidative stress in Alzheimer's mice, suggesting targeted antioxidants could offer neuroprotection.

Cite This Study

Calvo-Rodríguez et al. (2022) studied this question.

synapsesocial.com/papers/6a815430878fbc248522f6ee https://doi.org/10.1101/2022.06.12.495840

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Implication

In vivo imaging study reveals amyloid beta aggregates drive neuronal mitochondrial oxidative stress in Alzheimer's mice, suggesting targeted antioxidants could offer neuroprotection.

Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease

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Discussion

Implication

Cite This Study

Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease

Key Points

Discussion

Implication

Cite This Study

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