To the Editor: Spread of multidrug-resistant Neisseria gonorrhoeae is a major public health concern. Effective antimicrobial therapy is a key element in gonorrhea control. However, N. gonorrhoeae has developed resistance to multiple classes of antimicrobial drugs, including -lactams, tetracyclines, and fl uoroquinolones (1-3). Even an extended-spectrum oral cephalosporin-resistant, cefi ximeresistant N. gonorrhoeae has emerged, and cefi xime has now been withdrawn from use in Japan. Best practice treatment is limited to injectable extended-spectrum cephalosporins, such as ceftriaxone and spectinomycin. The emergence of ceftriaxone-resistant N. gonorrhoeae threatens effective disease control.
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Ohnishi et al. (2010) studied this question.
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