Why the study?
Do moxifloxacin and azithromycin cause Torsades de pointes arrhythmias in a susceptible animal model?
Population
Transfected HEK cells and 6 anaesthetized dogs with chronic AV block
Comparison
Moxifloxacin and Azithromycin vs Dofetilide (25 microg/kg i.v.)
Design
Preclinical
Authors
Loading...
These agents show no TdP risk despite QTc effects in dogs; extends dissociation of QT prolongation from torsadogenicity but leaves open human relevance.
Do moxifloxacin and azithromycin cause Torsades de pointes arrhythmias in a susceptible animal model?
Moxifloxacin and azithromycin do not cause Torsades de pointes in a susceptible dog model, suggesting they lack proarrhythmic properties despite moxifloxacin's known QTc prolongation.
Thomsen et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: