June 1, 1992Tumori Journal

Osteosarcoma of the Extremity Metastatic at Presentation: Results Achieved in 26 Patients Treated with Combined Therapy (Primary Chemotherapy Followed by Simultaneous Resection of the Primary and Metastatic Lesions)

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Why the study?

Does combined therapy (primary chemotherapy followed by surgery) improve outcomes in patients with high-grade osteosarcoma of the extremities metastatic at presentation?

Population

26 selected patients with high-grade osteosarcoma of the extremities metastatic at presentation

Comparison

Primary chemotherapy followed by surgery, then… vs 144 cases of non-metastatic osteosarcoma of the…

Design

Case_series

Follow-up

average 3.5 years

Authors

GBGaetano BacciIstituto Ortopedico Gaetano Pini PPPiero PicciUniversité Paris-Sud ABA BriccoliUniversity of Modena and Reggio Emilia

Discussion

Member takes

Implication

Metastatic osteosarcoma at presentation portends poor survival despite neoadjuvant chemotherapy; leaves open need for novel regimens in prospective trials.

Structured PICO

Does combined therapy (primary chemotherapy followed by surgery) improve outcomes in patients with high-grade osteosarcoma of the extremities metastatic at presentation?

Population

26 selected patients with high-grade osteosarcoma of the extremities metastatic at presentation

Intervention

Primary chemotherapy (high doses of methotrexate, cisplatinum, and adriamycin) followed by surgery (simultaneous resection of primary and metastatic lesions), then postoperative chemotherapy (same drugs plus ifosfamide and VP-16)

Comparator

144 cases of non-metastatic osteosarcoma of the extremities treated in the same period with the same preoperative chemotherapy

Outcome

Histologic response (percentage of tumor necrosis) and disease-free survivalhard clinical

Neoadjuvant chemotherapy that is highly effective for nonmetastatic osteosarcoma yields disappointing histologic responses and survival outcomes in patients presenting with metastatic disease.

Cite This Study

Bacci et al. (1992) studied this question.

synapsesocial.com/papers/6a8159e4a0713f3198f0961d https://doi.org/10.1177/030089169207800311

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Implication

Metastatic osteosarcoma at presentation portends poor survival despite neoadjuvant chemotherapy; leaves open need for novel regimens in prospective trials.

Osteosarcoma of the Extremity Metastatic at Presentation: Results Achieved in 26 Patients Treated with Combined Therapy (Primary Chemotherapy Followed by Simultaneous Resection of the Primary and Metastatic Lesions)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Osteosarcoma of the Extremity Metastatic at Presentation: Results Achieved in 26 Patients Treated with Combined Therapy (Primary Chemotherapy Followed by Simultaneous Resection of the Primary and Metastatic Lesions)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider