Relationship between Serum Renin Concentration, Renal Renin Content, and Juxtaglomerular Apparatus in Hypertensive Patients

On a variety of 30 hypertensive patients and 3 controls, relationship between serum renin concentration, renal renin content, and juxtaglomerular apparatus (JGA) was studied. A highly significant correlation was found between serum renin concentration and renal renin content. The correlations between serum renin concentration and juxtaglomerular granulation index (JGI), and between renal renin content and JGI were also significant. The correlation coefficients, however, were significantly lower than that between serum renin and renal renin. Several factors including staining techniques may be related to this difference. From these results, it is concluded that renin levels are related to the changes in the JGA on a variety of hypertensive patients, although these relations are still problematic in a few cases.