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January 1, 1959Experimental Biology and Medicine

Correlation between Granulation of Juxtaglomerular Cells and Extractable Renin in Rats with Experimental Hypertension.

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Population

Rats

Comparison

Experimental hypertension models vs Normal rat kidneys and 'untouched' contralateral…

Design

Preclinical

Authors

LTLouis TobianGeneral / Preventive / LipidsJJJames JanecekUniversity of MinnesotaATAlice TomboulianUniversity of Minnesota

Discussion

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Implication

May link juxtaglomerular granules to renin in rat hypertension models; hypothesis-generating and leaves open human relevance.

Key Points

  • The aim is to investigate the relationship between juxtaglomerular cell granulation and extractable renin in rat kidneys affected by hypertension.
  • Comparison of kidney tissues from normal rats and those with narrowed renal arteries.
  • Assessment of juxtaglomerular cell granulation and extractable renin levels.
  • Observation of the depressor response in renal extracts.
  • Normal kidneys show abundant juxtaglomerular granules and high extractable renin levels.
  • Kidneys from desoxycorticosterone hypertensive rats exhibit near absence of granules and renin.
  • A striking correlation exists between granulation and renin levels, supporting a potential link.

Structured PICO

P
Population
Rats (normal, with narrowed renal artery, with desoxycorticosterone hypertension, and with unilateral renal hypertension)
I
Intervention
Experimental hypertension models (narrowed renal artery, desoxycorticosterone)
C
Comparator
Normal rat kidneys and 'untouched' contralateral kidneys
O
Outcome
Correlation between juxtaglomerular granulation and extractable reninsurrogate

The study demonstrates a strong correlation between juxtaglomerular granulation and extractable renin in rat kidneys, supporting the hypothesis that these granules may be composed of renin.

Cite This Study

Tobian et al. (1959) studied this question.

synapsesocial.com/papers/6a70ab3ee36a167817e27d2bhttps://doi.org/10.3181/00379727-100-24535

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal Juxtaglomerular Cell Granulation in Acute and Prolonged Increase in Renin Production Induced by Hydralazine in the Rat1968 · 2 citations
  2. 2The Early Effect of Unilateral Nephrectomy on the Degree of Juxtaglomerular Cell Granulation and Blood Pressure in the Rat1968 · 1 citations
  3. 3Light and ultrastructural studies of renin granules in methacrylate and epon embedded kidneys1984
  4. 4Granular juxtaglomerular cells and prorenin synthesis in mice treated with enalapril1990 · 33 citations
  5. 5Immunohistochemical Findings of Juxtaglomerular Cells on Acute Phase in Two-Kidney Goldblatt Hypertensive Rats and Spontaneously Hypertensive Rats.1992 · 3 citations