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April 1, 1990Toxicologic Pathology

Ultrastructural Juxtaglomerular Cell Changes in Normotensive Rats Treated with Quinapril, an Inhibitor of Angiotensin-Converting Enzyme

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Why the study?

Does quinapril induce histologic and ultrastructural changes in the juxtaglomerular apparatus of normotensive rats?

Population

Normotensive male rats

Comparison

Quinapril 10, 100, and 400 mg/kg administered… vs Age-matched controls (0 mg/kg)

Design

Preclinical

Follow-up

up to 4 weeks

Authors

MDMark A. DominickBristol-Myers Squibb (United States)WBWalter F. BobrowskiPfizer (United States)AMAlan L. Mvetz

Discussion

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Implication

May indicate compensatory JGA adaptation in rats; leaves open relevance to human ACE inhibitor therapy.

Structured PICO

Does quinapril induce histologic and ultrastructural changes in the juxtaglomerular apparatus of normotensive rats?

P
Population
Normotensive male rats
I
Intervention
Quinapril 10, 100, and 400 mg/kg administered daily by gavage for up to 4 weeks
C
Comparator
Age-matched controls (0 mg/kg)
O
Outcome
Sequential histologic and ultrastructural changes in juxtaglomerular apparatus (JGA)surrogate

Subchronic ACE inhibition with quinapril rapidly induces juxtaglomerular cell hypertrophy and hyperplasia, reflecting stimulated renin synthesis and secretion.

Cite This Study

Dominick et al. (1990) studied this question.

synapsesocial.com/papers/6a7ab9dc02ab7a73dd03100bhttps://doi.org/10.1177/019262339001800306
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Role of the Renin-Angiotensin-Aldosterone and Kallikrein-Kinin Systems in the Control of Fluid and Electrolyte Metabolism, Renal Function, and Arterial Blood Pressure1982 · 10 citations