May 1, 1995Toxicologic Pathology

The Morphology of Juxtaglomerular Cell Hyperplasia and Hypertrophy in Normotensive Rats and Monkeys Given an Angiotensin II Receptor Antagonist

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Population

Normotensive rats and monkeys

Comparison

L-694,492, an angiotensin II receptor… vs Controls

Design

Preclinical

Follow-up

Up to 6 months of treatment, plus 3 months post-withdrawal

Authors

RORobin OwenLiverpool Hope University SMSylvain Molon-NoblotMerck & Co., Inc., Rahway, NJ, USA (United States)MHMarie-Françoise HubertTxcell (France)

Discussion

Member takes

Implication

Primate JG hyperplasia with ARBs may confound renin assays; leaves open human relevance and long-term effects.

Structured PICO

Population

Normotensive rats and monkeys

Intervention

L-694,492 (DUP 532), an angiotensin II (AII) receptor antagonist, given orally at 125 mg/kg/day for up to 6 months

Comparator

Controls

Outcome

Effects on juxtaglomerular (JG) cells, including hypertrophy, hyperplasia, and renal renin contentsurrogate

Angiotensin II receptor antagonism stimulates increased renal renin production through hypertrophy, metaplasia, and proliferation of juxtaglomerular cells, with increased cell numbers persisting even after drug withdrawal.

Cite This Study

Owen et al. (1995) studied this question.

synapsesocial.com/papers/6a7ab9dc02ab7a73dd031005 https://doi.org/10.1177/019262339502300319

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May 1, 1995Toxicologic Pathology

The Morphology of Juxtaglomerular Cell Hyperplasia and Hypertrophy in Normotensive Rats and Monkeys Given an Angiotensin II Receptor Antagonist

View Full Paper

Ask AI

Bookmark

Population

Normotensive rats and monkeys

Comparison

L-694,492, an angiotensin II receptor… vs Controls

Design

Preclinical

Follow-up

Up to 6 months of treatment, plus 3 months post-withdrawal

Authors

RORobin OwenLiverpool Hope University SMSylvain Molon-NoblotMerck & Co., Inc., Rahway, NJ, USA (United States)MHMarie-Françoise HubertTxcell (France)

Discussion

Member takes

Implication

Primate JG hyperplasia with ARBs may confound renin assays; leaves open human relevance and long-term effects.

Structured PICO

Population

Normotensive rats and monkeys

Intervention

L-694,492 (DUP 532), an angiotensin II (AII) receptor antagonist, given orally at 125 mg/kg/day for up to 6 months

Comparator

Controls

Outcome

Effects on juxtaglomerular (JG) cells, including hypertrophy, hyperplasia, and renal renin contentsurrogate

Cite This Study

Owen et al. (1995) studied this question.

synapsesocial.com/papers/6a7ab9dc02ab7a73dd031005 https://doi.org/10.1177/019262339502300319

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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