Why the study?
Does angiotensin II receptor antagonism with L-694,492 affect juxtaglomerular cell morphology and renin production in normotensive rats and monkeys?
Population
Normotensive rats and monkeys
Comparison
L-694,492, an angiotensin II receptor… vs Controls
Design
Preclinical
Follow-up
Up to 6 months of treatment, plus 3 months post-withdrawal
Authors
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Animal data on ARB-induced JG changes remain hypothesis-generating; prospective human studies needed before clinical consideration.
Does angiotensin II receptor antagonism with L-694,492 affect juxtaglomerular cell morphology and renin production in normotensive rats and monkeys?
Angiotensin II receptor antagonism stimulates renal renin production through hypertrophy, metaplasia, and proliferation of juxtaglomerular cells, with increased cell numbers persisting after drug withdrawal.
Owen et al. (1994) studied this question.
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