January 1, 1968Scandinavian Journal of Urology and Nephrology

Renal Juxtaglomerular Cell Granulation in Acute and Prolonged Increase in Renin Production Induced by Hydralazine in the Rat

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Why the study?

Does hydralazine-induced renin production increase juxtaglomerular cell granulation in rats?

Population

Rats (two series: acute bleeding model and 10-day renal artery clipping model)

Comparison

Hydralazine administration combined with… vs Pentolinium administration or implied controls

Design

Preclinical

Follow-up

30 minutes (acute model), 10 days (prolonged model)

Authors

LBLjubomir BoźovićKarolinska University Hospital JCJan CastenforsStockholm South General Hospital ALArne LjungqvistAnti-Doping Laboratory

Discussion

Member takes

Implication

Early renin increases may precede visible granulation in rats; leaves open reliability of granulation as an early marker in clinical research.

Structured PICO

Does hydralazine-induced renin production increase juxtaglomerular cell granulation in rats?

Population

Rats (two series: acute bleeding model and 10-day renal artery clipping model)

Intervention

Hydralazine administration combined with bleeding (acute model) or renal artery clipping (prolonged model)

Comparator

Pentolinium administration (in acute model) or implied controls

Outcome

Plasma renin activity, kidney renin content, and degree of juxtaglomerular cell granulationsurrogate

Increased renin production and release can occur without perceptible increases in juxtaglomerular cell granulation in rat models.

Cite This Study

Boźović et al. (1968) studied this question.

synapsesocial.com/papers/6a815ab30914b5fb8de3fceb https://doi.org/10.3109/00365596809135361

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January 1, 1968Scandinavian Journal of Urology and Nephrology

Renal Juxtaglomerular Cell Granulation in Acute and Prolonged Increase in Renin Production Induced by Hydralazine in the Rat

View Full Paper

Ask AI

Bookmark

Why the study?

Does hydralazine-induced renin production increase juxtaglomerular cell granulation in rats?

Population

Rats (two series: acute bleeding model and 10-day renal artery clipping model)

Comparison

Hydralazine administration combined with… vs Pentolinium administration or implied controls

Design

Preclinical

Follow-up

30 minutes (acute model), 10 days (prolonged model)

Authors

LBLjubomir BoźovićKarolinska University Hospital JCJan CastenforsStockholm South General Hospital ALArne LjungqvistAnti-Doping Laboratory

Discussion

Member takes

Implication

Early renin increases may precede visible granulation in rats; leaves open reliability of granulation as an early marker in clinical research.

Structured PICO

Does hydralazine-induced renin production increase juxtaglomerular cell granulation in rats?

Population

Rats (two series: acute bleeding model and 10-day renal artery clipping model)

Intervention

Hydralazine administration combined with bleeding (acute model) or renal artery clipping (prolonged model)

Comparator

Pentolinium administration (in acute model) or implied controls

Outcome

Plasma renin activity, kidney renin content, and degree of juxtaglomerular cell granulationsurrogate

Increased renin production and release can occur without perceptible increases in juxtaglomerular cell granulation in rat models.

Cite This Study

Boźović et al. (1968) studied this question.

synapsesocial.com/papers/6a815ab30914b5fb8de3fceb https://doi.org/10.3109/00365596809135361

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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