Key result
Changes in renal perfusion pressure and mineralocorticoid activity markedly affect the granularity of juxtaglomerular cells, implicating them in renin production.
The juxtaglomerular cells are implicated in renin production and respond to hemodynamic and mineralocorticoid changes.
A considerable body of experimental data has accumulated to implicate the cells of the juxtaglomerular apparatus in the production and release of "renin" by the kidney. Since the juxtaglomerular cells lie in the wall of the afferent arteriole they are in a perfect location to appreciate hemodynamic changes within the kidney.1 Marked changes in the granularity of these cells can be demonstrated in response to changes in the perfusion pressure of the kidney.2 Granularity is also markedly affected by changes in mineralocorticoid activity of the adrenal cortex.2 The changes observed are in accord with the interpretation that granularity is an . . .
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A 1962 study conducted a review in Renal Hypertension. Changes in perfusion pressure and mineralocorticoid activity was evaluated on Granularity of juxtaglomerular cells. Changes in renal perfusion pressure and mineralocorticoid activity markedly affect the granularity of juxtaglomerular cells, implicating them in renin production.
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