Why the study?
Does sematilide prevent or aggravate ventricular arrhythmias in canine models?
Does sematilide prevent or aggravate ventricular arrhythmias in canine models?
In canine models, the class III agent sematilide showed limited antiarrhythmic efficacy specific to reentrant arrhythmias and exhibited proarrhythmic effects in automaticity models.
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Sematilide shows limited, arrhythmia-specific effects in dogs; leaves open net benefit or harm in human ventricular arrhythmias.
Yi et al. (1996) studied this question.
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