Why the study?
Coxsackievirus A-16 is currently circulating and causing outbreaks of hand, foot and mouth disease in India.
CVA-16 tropism primarily targets skeletal muscle, brain, and cardiac tissues in a neonatal mouse model.
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Suggests cardiac monitoring in CVA-16; leaves open translation from neonatal mouse model to humans.
Hand, foot and mouth disease (HFMD) is a paediatric disease associated with enteroviruses (EVs). Among EVs, coxsackievirus A-16 (CVA-16) strain is currently in circulation and causing outbreaks in India. Neonatal mice (Institute of Cancer Research) strains were infected with CVA-16 strain isolated from HFMD patients to conduct pathological and molecular studies. Infected organs were harvested as per time points. A real-time polymerase chain reaction was used for qualitative estimation of viral RNA in organ tissues of infected mice. Skeletal muscle, brain tissue and cardiac tissues were the major target sites of CVA-16 tropism. The first-ever study was conducted on CVA-16 strains using the current approach in India.
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Tikute et al. (2020) studied this question.
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